{"id":422,"date":"2019-02-26T18:22:30","date_gmt":"2019-02-26T09:22:30","guid":{"rendered":"http:\/\/slfn11.iab.keio.ac.jp\/?page_id=422"},"modified":"2023-11-09T10:59:43","modified_gmt":"2023-11-09T01:59:43","slug":"tests-en","status":"publish","type":"page","link":"https:\/\/slfn11.iab.keio.ac.jp\/?page_id=422","title":{"rendered":"Publication"},"content":{"rendered":"\n
<\/div>\n\n\n\n

Yasuhisa Murai, Ukhyun Jo, Junko Murai, Lisa M Jenkins, Shar-Yin N Huang, Sirisha Chakka, Lu Chen, Ken Cheng, Shinsaku Fukuda, Naoko Takebe, Yves Pommier\uff0a
SLFN11 inactivation induces proteotoxic stress and sensitizes cancer cells to ubiquitin activating enzyme inhibitor TAK-243<\/strong>
Cancer Research\u30fb81(11)\u30fb3067-3078\u30fb2021  [ PMID : 33863777<\/strong><\/a> ]<\/p>\n\n\n\n

Tsuyoshi Takashima, Daiki Taniyama, Naoya Sakamoto\uff0a, Maika Yasumoto, Ryuichi Asai, Takuya Hattori, Ririno Honma, Pham Quoc Thang, Shoichi Ukai, Ryota Maruyama, Kenji Harada, Kazuya Kuraoka, Kazuaki Tanabe, Atsuo T Sasaki, Hideki Ohdan, Eiichi Morii, Junko Murai\uff0a, Wataru Yasui
Schlafen 11 predicts response to platinum-based chemotherapy in gastric cancers<\/strong>
British Journal of Cancer\u30fb125(1)\u30fb65-77\u30fb2021  [ PMID : 33785877<\/a><\/strong> ]<\/p>\n\n\n\n

Tsuyoshi Takashima, Naoya Sakamoto, Junko Murai, Daiki Taniyama, Ririno Honma, Shoichi Ukai, Ryota Maruyama, Kazuya Kuraoka, Vinodh N Rajapakse, Yves Pommier, Wataru Yasui\uff0a
Immunohistochemical analysis of SLFN11 expression uncovers potential non-responders to DNA-damaging agents overlooked by tissue RNA-seq<\/strong>
Virchows Archiv\u30fb478(3)\u30fb569-579\u30fb2021  [ PMID : 32474729<\/a><\/strong> ]<\/p>\n\n\n\n

Ukhyun Jo\uff0a, Yasuhisa Murai, Sirisha Chakka, Lu Chen, Ken Cheng, Junko Murai, Liton Kumar Saha, Lisa M Miller Jenkins, Yves Pommier\uff0a
SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR\/CHK1 inhibitors<\/strong>
Proceedings of the National Academy of Sciences\u30fb118(6)\u30fbe2015654118\u30fb2021  [ PMID : 33536335<\/a><\/strong> ]<\/p>\n\n\n\n

Fumiya Moribe, Momoko Nishikori\uff0a, Tsuyoshi Takashima, Daiki Taniyama, Nobuyuki Onishi, Hiroshi Arima, Hiroyuki Sasanuma, Remi Akagawa, Fathi Elloumi, Shunichi Takeda, Yves Pommier, Eiichi Morii, Akifumi Takaori-Kondo, Junko Murai\uff0a
Epigenetic suppression of SLFN11 in germinal center B-cells during B-cell development<\/strong>
PloS one\u30fb16(1)\u30fbe0237554\u30fb2021  [ PMID : 33513156<\/a><\/strong> ] <\/p>\n\n\n\n

Takuma Kagami, Mihoko Yamade, Takahiro Suzuki, Takahiro Uotani, Shinya Tani, Yasushi Hamaya, Moriya Iwaizumi, Satoshi Osawa, Ken Sugimoto, Hiroaki Miyajima, Satoshi Baba, Haruhiko Sugimura, Junko Murai, Yves Pommier, Takahisa Furuta\uff0a
The first evidence for SLFN11 expression as an independent prognostic factor for patients with esophageal cancer after chemoradiotherapy<\/strong>
BMC cancer\u30fb20(1)\u30fb1123\u30fb2020  [ PMID : 33218331<\/a><\/strong> ] <\/p>\n\n\n\n

Lorinc S Pongor, Jacob M Gross, Roberto Vera Alvarez, Junko Murai, Sang-Min Jang, Hongliang Zhang, Christophe Redon, Haiqing Fu, Shar-Yin Huang, Bhushan Thakur, Adrian Baris, Leonardo Marino-Ramirez, David Landsman, Mirit I Aladjem, Yves Pommier\uff0a
BAMscale: quantification of next-generation sequencing peaks and generation of scaled coverage tracks<\/strong>
Epigenetics & chromatin\u30fb13(1)\u30fb21\u30fb2020  [ PMID : 32321568<\/strong><\/a> ]<\/p>\n\n\n\n

Jayakumar Nair\uff0a, Tzu-Ting Huang, Junko Murai, Brittany Haynes, Patricia S Steeg, Yves Pommier, Jung-Min Lee
Resistance to the CHK1 inhibitor prexasertib involves functionally distinct CHK1 activities in BRCA wild-type ovarian cancer<\/strong>
Oncogene\u30fb39 (33)\u30fb5520-5535\u30fb2020 [ PMID : 32647134<\/a><\/strong> ]<\/p>\n\n\n\n

Daniel Rathkey, Manakamana Khanal, Junko Murai, Jingli Zhang, Manjistha Sengupta, Qun Jiang, Betsy Morrow, Christine N Evans, Raj Chari, Patricia Fetsch, Hye-Jung Chung, Liqiang Xi, Mark Roth, Armando Filie, Mark Raffeld, Anish Thomas, Yves Pommier, Raffit Hassan\uff0a
Sensitivity of mesothelioma cells to PARP inhibitors is not dependent on BAP1 but is enhanced by temozolomide in cells with high-Schlafen 11 and low-O6-methylguanine-DNA methyltransferase expression<\/strong>
Journal of Thoracic Oncology\u30fb15 (5)\u30fb843-859\u30fb2020 [ PMID : 32004714<\/a><\/strong> ] <\/p>\n\n\n\n

Junko Murai\uff0a, Hongliang Zhang, Lorinc Pongor, Sai-Wen Tang, Ukhyun Jo, Fumiya Moribe, Yixiao Ma, Masaru Tomita, Yves Pommier\uff0a
Chromatin remodeling and immediate early gene activation by SLFN11 in response to replication stress<\/strong>
Cell reports\u30fb30 (12)\u30fb4137-4151. E6\u30fb2020 [ PMID : 32209474<\/a><\/strong> ]<\/p>\n\n\n\n

Laetitia Marzi, Ludmila Szabova, Melanie Gordon, Zoe Weaver Ohler, Shyam K Sharan, Michael L Beshiri, Moudjib Etemadi, Junko Murai, Kathleen Kelly, Yves Pommier\uff0a
The indenoisoquinoline TOP1 inhibitors selectively target homologous recombination-deficient and schlafen 11-positive cancer cells and synergize with olaparib<\/strong>
Clinical Cancer Research\u30fb25 (20)\u30fb6206-6216\u30fb2019 [ PMID : 31409613<\/a><\/strong> ] <\/p>\n\n\n\n

Laetitia Marzi, Keli Agama, Junko Murai, Simone Difilippantonio, Amy James, Cody J Peer, William D Figg, Daniel Beck, Mohamed SA Elsayed, Mark Cushman, Yves Pommier\uff0a
Novel fluoroindenoisoquinoline non-camptothecin topoisomerase I inhibitors<\/strong>
Molecular cancer therapeutics\u30fb17 (8)\u30fb1694-1704\u30fb2018 [ PMID : 29748210<\/a><\/strong> ]<\/p>\n\n\n\n

Sai-Wen Tang, Anish Thomas, Junko Murai, Jane B Trepel, Susan E Bates, Vinodh N Rajapakse, Yves Pommier\uff0a
Overcoming resistance to DNA-targeted agents by epigenetic activation of Schlafen 11 (SLFN11) expression with class I histone deacetylase inhibitors<\/strong>
Clinical cancer research\u30fb24 (8)\u30fb1944-1953\u30fb2018 [ PMID : 29391350<\/a><\/strong> ]<\/p>\n\n\n\n

Shar\u2010yin N Huang, Ilaria Dalla Rosa, Stephanie A Michaels, David V Tulumello, Keli Agama, Salim Khiati, Sae Rin Jean, Simone A Baechler, Valentina M Factor, Sudhir Varma, Junko Murai, Lisa M Miller Jenkins, Shana O Kelley, Yves Pommier\uff0a
Mitochondrial tyrosyl\u2010DNA phosphodiesterase 2 and its TDP2S short isoform<\/strong>
EMBO reports\u30fb19 (3)\u30fbe42139\u30fb2018 [ PMID : 29438979<\/strong><\/a><\/strong> ] <\/p>\n\n\n\n

Junko Murai\uff0a, Sai-Wen Tang, Elisabetta Leo, Simone A Baechler, Christophe E Redon, Hongliang Zhang, Muthana Al Abo, Vinodh N Rajapakse, Eijiro Nakamura, Lisa M Miller Jenkins, Mirit I Aladjem, Yves Pommier\uff0a
SLFN11 blocks stressed replication forks independently of ATR<\/strong>
Molecular cell\u30fb69 (3)\u30fb371-384. E6\u30fb2018 [ PMID : 29395061<\/a><\/strong> ] , \u65e5\u672c\u8a9e\u30b5\u30de\u30ea\u30fc<\/a> <\/p>\n\n\n\n

Masataka Tsuda, Kosai Cho, Masato Ooka, Naoto Shimizu, Reiko Watanabe, Akira Yasui, Yuka Nakazawa, Tomoo Ogi, Hiroshi Harada, Keli Agama, Jun Nakamura, Ryuta Asada, Haruna Fujiike, Tetsushi Sakuma, Takashi Yamamoto, Junko Murai, Masahiro Hiraoka, Kaoru Koike, Yves Pommier, Shunichi Takeda, Kouji Hirota\uff0a
ALC1\/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair<\/strong>
PloS one\u30fb12 (11)\u30fbe0188320\u30fb2017 [ PMID : 29149203<\/a><\/strong> ] <\/p>\n\n\n\n

Peter M Bruno, Yunpeng Liu, Ga Young Park, Junko Murai, Catherine E Koch, Timothy J Eisen, Justin R Pritchard, Yves Pommier, Stephen J Lippard, Michael T Hemann\uff0a
A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress<\/strong>
Nature medicine\u30fb23 (4)\u30fb461-471\u30fb2017 [ PMID : 28263311<\/a><\/strong> ] <\/p>\n\n\n\n

Junko Murai, Ying Feng, K Yu Guoying, Yuanbin Ru, Sai-Wen Tang, Yuqiao Shen, Yves Pommier\uff0a
Resistance to PARP inhibitors by SLFN11 inactivation can be overcome by ATR inhibition<\/strong>
Oncotarget\u30fb7 (47)\u30fb76534\u30fb2016 [ PMID : 27708213<\/a><\/strong> ]<\/p>\n\n\n\n

Kouji Hirota\uff0a, Masataka Tsuda, Toshiki Tsurimoto, Isadora S Cohen, Zvi Livneh, Kaori Kobayashi, Takeo Narita, Kana Nishihara, Junko Murai, Shigenori Iwai, Guillaume Guilbaud, Julian E Sale, Shunichi Takeda\uff0a
In vivo evidence for translesion synthesis by the replicative DNA polymerase \u03b4<\/strong>
Nucleic acids research\u30fb44 (15)\u30fb7242-7250\u30fb2016 [ PMID : 27185888<\/a><\/strong> ] <\/p>\n\n\n\n

Sai-Wen Tang, Sven Bilke, Liang Cao, Junko Murai, Fabricio G Sousa, Mihoko Yamade, Vinodh Rajapakse, Sudhir Varma, Lee J Helman, Javed Khan, Paul S Meltzer, Yves Pommier\uff0a
SLFN11 is a transcriptional target of EWS-FLI1 and a determinant of drug response in Ewing sarcoma<\/strong>
Clinical Cancer Research\u30fb21 (18)\u30fb4184-4193\u30fb2015 [ PMID : 25779942<\/a><\/strong> ]<\/p>\n\n\n\n

Kouji Hirota, Kazunori Yoshikiyo, Guillaume Guilbaud, Toshiki Tsurimoto, Junko Murai, Masataka Tsuda, Lara G Phillips, Takeo Narita, Kana Nishihara, Kaori Kobayashi, Kouich Yamada, Jun Nakamura, Yves Pommier, Alan Lehmann, Julian E Sale, Shunichi Takeda\uff0a
The POLD3 subunit of DNA polymerase \u03b4 can promote translesion synthesis independently of DNA polymerase \u03b6<\/strong>
Nucleic acids research\u30fb43 (3)\u30fb1671-1683\u30fb2015 [ PMID : 25628356<\/a><\/strong> ] <\/p>\n\n\n\n

Junko Murai, Christophe Marchand, Sampada A Shahane, Hongmao Sun, Ruili Huang, Yiping Zhang, Adel Chergui, Jiuping Ji, James H Doroshow, Ajit Jadhav, Shunichi Takeda, Menghang Xia, Yves Pommier\uff0a
Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform<\/strong>
DNA repair\u30fb21\u30fb177-182\u30fb2014 [ PMID : 24794403<\/a><\/strong> ] <\/p>\n\n\n\n

Maulik R Patel, Aaditya Bhatt, Jamin D Steffen, Adel Chergui, Junko Murai, Yves Pommier, John M Pascal, Louis D Trombetta, Frank R Fronczek, Tanaji T Talele\uff0a
Discovery and Structure\u2013Activity Relationship of Novel 2, 3-Dihydrobenzofuran-7-carboxamide and 2, 3-Dihydrobenzofuran-3 (2 H)-one-7-carboxamide Derivatives as Poly (ADP-ribose) polymerase-1 Inhibitors<\/strong>
DNA repair\u30fb21\u30fb177-182\u30fb2014 [ PMID : 24922587<\/strong><\/a> ] <\/p>\n\n\n\n

Junko Murai, Yiping Zhang, Joel Morris, Jiuping Ji, Shunichi Takeda, James H Doroshow, Yves Pommier\uff0a
Rationale for poly (ADP-ribose) polymerase (PARP) inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition<\/strong>
Journal of Pharmacology and Experimental Therapeutics\u30fb349(3)\u30fb408-416\u30fb2014 [ PMID : 24650937<\/a><\/strong> ] <\/p>\n\n\n\n

Benu Brata Das, Shar-yin N Huang, Junko Murai, Ishita Rehman, Jean-Christophe Ame, Souvik Sengupta, Subhendu K Das, Papiya Majumdar, Hongliang Zhang, Denis Biard, Hemanta K Majumder, Valerie Schreiber, Yves Pommier\uff0a
PARP1\u2013TDP1 coupling for the repair of topoisomerase I\u2013induced DNA damage<\/strong>
Nucleic acids research\u30fb42(7)\u30fb4435-4449\u30fb2014 [ PMID : 24493735<\/strong><\/a> ] <\/p>\n\n\n\n

Junko Murai, Shar-Yin N Huang, Am\u00e8lie Renaud, Yiping Zhang, Jiuping Ji, Shunichi Takeda, Joel Morris, Beverly Teicher, James H Doroshow, Yves Pommier\uff0a
Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib<\/strong>
Molecular cancer therapeutics\u30fb13(2)\u30fb433-443\u30fb2014 [ PMID : 24356813<\/a><\/strong> ] <\/p>\n\n\n\n

Yuko Maede, Hiroyasu Shimizu, Toru Fukushima, Toshiaki Kogame, Terukazu Nakamura, Tsuneharu Miki, Shunichi Takeda, Yves Pommier\uff0a, Junko Murai\uff0a
Differential and common DNA repair pathways for topoisomerase I-and II-targeted drugs in a genetic DT40 repair cell screen panel<\/strong>
Molecular cancer therapeutics\u30fb13(1)\u30fb214-220\u30fb2014 [ PMID : 24130054<\/a><\/strong> ] <\/p>\n\n\n\n

Shar-yin N Huang, Junko Murai, Ilaria Dalla Rosa, Thomas S Dexheimer, Alena Naumova, William H Gmeiner, Yves Pommier\uff0a
TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs<\/strong>
Nucleic acids research\u30fb41(16)\u30fb7793-7803\u30fb2013 [ PMID : 23775789<\/a><\/strong> ] <\/p>\n\n\n\n

Junko Murai, N Huang Shar-yin, Benu Brata Das, Amelie Renaud, Yiping Zhang, James H Doroshow, Jiuping Ji, Shunichi Takeda, Yves Pommier\uff0a
Trapping of PARP1 and PARP2 by clinical PARP inhibitors<\/strong>
Cancer research\u30fb72(21)\u30fb5588-5599\u30fb2012 [ PMID : 23118055<\/strong><\/a> ] <\/p>\n\n\n\n

Zhihong Zeng, Abhishek Sharma, Limei Ju, Junko Murai, Lieve Umans, Liesbeth Vermeire, Yves Pommier, Shunichi Takeda, Danny Huylebroeck, Keith W Caldecott, Sherif F El-Khamisy\uff0a
TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1<\/strong>
Nucleic acids research\u30fb40(17)\u30fb8371-8380\u30fb2012 [ PMID : 22740648<\/a><\/strong> ] <\/p>\n\n\n\n

Junko Murai, N Huang Shar-yin, Benu Brata Das, Thomas S Dexheimer, Shunichi Takeda, Yves Pommier\uff0a
Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells<\/strong>
Journal of Biological Chemistry\u30fb287(16)\u30fb12848-12857\u30fb2012 [ PMID : 22375014<\/a><\/strong> ] <\/p>\n\n\n\n

Mina Okamoto, Junko Murai, Yuuki Imai, Daisuke Ikegami, Nobuhiro Kamiya, Shigeaki Kato, Yuji Mishina, Hideki Yoshikawa, Noriyuki Tsumaki\uff0a
Conditional deletion of Bmpr1a in differentiated osteoclasts increases osteoblastic bone formation, increasing volume of remodeling bone in mice<\/strong>
Journal of Bone and Mineral Research\u30fb26(10)\u30fb2511-2522\u30fb2011 [ PMID : 21786321<\/a><\/strong> ] <\/p>\n\n\n\n

Kailin Yang, George-Lucian Moldovan, Patrizia Vinciguerra, Junko Murai, Shunichi Takeda, Alan D D’Andrea\uff0a
Regulation of the Fanconi anemia pathway by a SUMO-like delivery network<\/strong>
Genes & development\u30fb25(17)\u30fb1847-1858\u30fb2011 [ PMID : 21896657<\/a><\/strong> ] <\/p>\n\n\n\n

Junko Murai, Kailin Yang, Donniphat Dejsuphong, Kouji Hirota, Shunichi Takeda, Alan D D’Andrea\uff0a
The USP1\/UAF1 complex promotes double-strand break repair through homologous recombination<\/strong>
Molecular and cellular biology\u30fb31(12)\u30fb2462-2469\u30fb2011 [ PMID : 21482670<\/a><\/strong> ] <\/p>\n\n\n\n

Junko Murai, Daisuke Ikegami, Mina Okamoto, Hideki Yoshikawa, Noriyuki Tsumaki\uff0a
Insulation of the ubiquitous Rxrb promoter from the cartilage-specific adjacent gene, Col11a2<\/strong>
Journal of Biological Chemistry\u30fb283(41)\u30fb27677-27687\u30fb2008 [ PMID : 18682388<\/a><\/strong> ] <\/p>\n\n\n\n

Takao Iwai, Junko Murai, Hideki Yoshikawa, Noriyuki Tsumaki\uff0a
Smad7 Inhibits Chondrocyte Differentiation at Multiple Steps during Endochondral Bone Formation and Down-regulates p38 MAPK Pathways<\/strong>
Journal of Biological Chemistry\u30fb283(40)\u30fb27154-27164\u30fb2008 [ PMID : 18644788<\/a><\/strong> ] <\/p>\n\n\n\n

Takao Iwai, Yoshifumi Harada, Koichi Imura, Sadahiro Iwabuchi, Junko Murai, Kunihiko Hiramatsu, Akira Myoui, Hideki Yoshikawa, Noriyuki Tsumaki\uff0a
Low-intensity pulsed ultrasound increases bone ingrowth into porous hydroxyapatite ceramic<\/strong>
Journal of bone and mineral metabolism\u30fb25(6)\u30fb392-399\u30fb2007 [ PMID : 17968491<\/strong><\/a> ]<\/p>\n\n\n\n

Mina Okamoto, Junko Murai, Hideki Yoshikawa, Noriyuki Tsumaki\uff0a
Bone morphogenetic proteins in bone stimulate osteoclasts and osteoblasts during bone development<\/strong>
Journal of Bone and Mineral Research\u30fb21(7)\u30fb1022-1033\u30fb2006 [ PMID : 16813523<\/a><\/strong> ] <\/p>\n\n\n\n

Mitsuru Horiki, Takeshi Imamura, Mina Okamoto, Makoto Hayashi, Junko Murai, Akira Myoui, Takahiro Ochi, Kohei Miyazono, Hideki Yoshikawa, Noriyuki Tsumaki\uff0a
Smad6\/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia<\/strong>
The Journal of cell biology\u30fb165(3)\u30fb433-445\u30fb2004 [ PMID : 15123739<\/a><\/strong> ] <\/p>\n\n\n\n

Junko Murai\uff0a, Anish Thomas, Markku Miettinen, Yves Pommier\uff0a
Schlafen 11 (SLFN11), a restriction factor for replicative stress induced by DNA-targeting anti-cancer therapies<\/strong>
Pharmacology & therapeutics\u30fb201\u30fb94-102\u30fb2019 (review) [ PMID : 31128155<\/a><\/strong> ] <\/p>\n\n\n\n

Junko Murai\uff0a, Yves Pommier\uff0a
PARP trapping beyond homologous recombination and platinum sensitivity in cancers<\/strong>
Annual Review of Cancer Biology\u30fb3\u30fb131-150\u30fb2019 Review<\/a><\/strong><\/em> <\/p>\n\n\n\n

Brittany Haynes, Junko Murai, Jung-Min Lee
Restored replication fork stabilization, a mechanism of PARP inhibitor resistance, can be overcome by cell cycle checkpoint inhibition<\/strong>
Cancer treatment reviews\u30fb71\u30fb1-7\u30fb2018 [ PMID : 30269007<\/a><\/strong> ] <\/p>\n\n\n\n

Junko Murai\uff0a
Targeting DNA repair and replication stress in the treatment of ovarian cancer<\/strong>
International journal of clinical oncology\u30fb22(4)\u30fb619-628\u30fb2017 [ PMID : 28643177<\/a><\/strong> ] <\/p>\n\n\n\n

Christophe Marchand, N Huang Shar-yin, Thomas S Dexheimer, Wendy A Lea, Bryan T Mott, Adel Chergui, Alena Naumova, Andrew G Stephen, Andrew S Rosenthal, Ganesha Rai, Junko Murai, Rui Gao, David J Maloney, Ajit Jadhav, William L Jorgensen, Anton Simeonov, Yves Pommier
Biochemical assays for the discovery of TDP1 inhibitors<\/strong>
Molecular cancer therapeutics\u30fb13(8)\u30fb2116-2126\u30fb2014 [ PMID : 25024006<\/strong><\/a> ] <\/p>\n\n\n\n

Yves Pommier, N Huang Shar-yin, Rui Gao, Benu Brata Das, Junko Murai, Christophe Marchand
Tyrosyl-DNA-phosphodiesterases (tdp1 and tdp2)<\/strong>
DNA repair\u30fb19\u30fb114-129\u30fb2014 [ PMID : 24856239<\/a><\/strong> ] <\/p>\n\n\n\n

\u6751\u4e95\u7d14\u5b50
PARP\u963b\u5bb3\u5264\u306e\u7a2e\u985e\u3068\u63a1\u7528\u6a5f\u5e8f (\u7279\u96c6 \u5375\u5de3\u764c\u306b\u304a\u3051\u308bHRD\u3068PARP\u963b\u5bb3\u85ac\u306e\u52b9\u679c)
\u7523\u5a66\u4eba\u79d1\u306e\u5b9f\u969b\u30fb70(5)\u30fb517-523\u30fb2021<\/p>\n\n\n\n

\u9ad8\u6a4b\u4f51\u6b4c,\u3000\u6751\u4e95\u7d14\u5b50
\u7720\u308a\u304b\u3089\u899a\u3081\u305fSchlafen 11 (SLFN11)
\u9031\u9593\u3000\u533b\u5b66\u306e\u3042\u3086\u307f\u30fb274(12)\u30fb1169-1174\u30fb2020<\/p>\n\n\n\n

\u6b66\u7530\u4fca\u4e00\uff0c \u6751\u4e95\u7d14\u5b50
\u907a\u4f1d\u5b66\u7684\u624b\u6cd5\u306e\u5fdc\u7528\u306b\u3088\u308b\u30b1\u30df\u30ab\u30eb\u30d0\u30a4\u30aa\u30ed\u30b8\u30fc\u306e\u65b0\u5c55\u958b
\u65e5\u672c\u8fb2\u85ac\u5b66\u4f1a\u8a8c\u30fb39(2)\u30fb137-144\u30fb2014<\/p>\n\n\n\n

\u6751\u4e95\u7d14\u5b50
\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u3068\u8131\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u306b\u3088\u308b DNA \u4fee\u5fa9\u306e\u8abf\u7bc0\u6a5f\u69cb (\u7279\u96c6 \u764c\u6cbb\u7642\u30fb\u767a\u764c\u30fb\u8001\u5316\u306e\u9375\u3092\u63e1\u308b DNA \u4fee\u5fa9\u7d4c\u8def)
\u7d30\u80de\u5de5\u5b66\u30fb29(1)\u30fb42-47\u30fb2010<\/p>\n\n\n\n

Junko Murai, Yves Pommier
PARP inhibitors for cancer therapy<\/strong>
Classification of PARP inhibitors based on PARP trapping and catalytic inhibition, and rationale for combinations with topoisomerase I inhibitors and alkylating agents<\/strong>
Humana Press, Cham\u30fb261-274\u30fb2015 Review<\/a><\/strong><\/em> <\/p>\n\n\n\n

Junko Murai, Yves Pommier
Phosphatase 1 nuclear targeting subunit, a novel DNA repair partner of PARP1<\/strong>
Cancer research\u30fb79(10)\u30fb2460-2461\u30fb2019 (Commentary) [ PMID : 31092408<\/a><\/strong> ] <\/p>\n\n\n\n

Anish Thomas, Junko Murai, Yves Pommier
The evolving landscape of predictive biomarkers of response to PARP inhibitors<\/strong>
The Journal of clinical investigation\u30fb128(5)\u30fb1727-1730\u30fb2018 (Commentary) [ PMID : 29664016<\/a><\/strong> ]
<\/p>\n\n\n\n

Alberto Ballestrero, Davide Bedognetti, Domenico Ferraioli, Paola Franceschelli, Sana Intidhar Labidi-Galy, Elisabetta Leo, Junko Murai, Yves Pommier, Petros Tsantoulis, Valerio Gaetano Vellone, Gabriele Zoppoli
Report on the first SLFN11 monothematic workshop: from function to role as a biomarker in cancer<\/strong>
Journal of translational medicine\u30fb15(1)\u30fb199\u30fb2017 (Conference report) [ PMID : 28969705<\/a><\/strong> ]
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Yasuhisa Murai, Ukhyun Jo, Junko Murai, Lisa M Jenkins, Shar-Yin N Huang, Sirisha Chakka, Lu Chen, Ken Cheng, Shinsaku Fukuda, Naoko Takebe, Yves Pommier\uff0aSLFN11 inactivation induces proteotoxic stress and sensitizes cancer cells to ubiquitin activating enzyme inhibitor TAK-243Cancer Research\u30fb81(11)\u30fb3067-3078\u30fb2021  [ PMID : 33863777 ] Tsuyoshi Takashima, Daiki Taniyama, Naoya Sakamoto\uff0a, Maika Yasumoto, Ryuichi Asai, Takuya … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":7,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":"","_locale":"en_US","_original_post":"24"},"_links":{"self":[{"href":"https:\/\/slfn11.iab.keio.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/422"}],"collection":[{"href":"https:\/\/slfn11.iab.keio.ac.jp\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/slfn11.iab.keio.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/slfn11.iab.keio.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/slfn11.iab.keio.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=422"}],"version-history":[{"count":25,"href":"https:\/\/slfn11.iab.keio.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/422\/revisions"}],"predecessor-version":[{"id":1155,"href":"https:\/\/slfn11.iab.keio.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/422\/revisions\/1155"}],"wp:attachment":[{"href":"https:\/\/slfn11.iab.keio.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=422"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}